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South Africa offers Cape Town's Table Mountain, the Garden Route, Kruger National Park safaris, and the winelands of Stellenbosch. No vaccinations are legally required for direct entry from the UK, but Yellow Fever certification is needed if arriving from an endemic country. Malaria is present in the north-east (Kruger, Limpopo, Mpumalanga, KwaZulu-Natal border areas) but absent from Cape Town, Johannesburg, and the Garden Route.
These vaccines may be required for entry to South Africa or if transiting through endemic areas.
£79/Total
These vaccines are strongly recommended for travel to South Africa. Our pharmacist will advise which are most relevant to your specific itinerary.
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Moderate Risk Level
Malaria risk is concentrated in the north-eastern provinces: Limpopo, Mpumalanga (including Kruger National Park), and northern KwaZulu-Natal. Risk is highest from October to May (summer/wet season). Cape Town, Johannesburg, Durban city, and the Garden Route are malaria-free. Anti-malarial tablets are recommended for Kruger safaris and north-eastern travel.

Practical tips to help you stay safe, healthy, and prepared throughout your trip.
Yellow Fever certificate required only if arriving from an endemic country (not needed for direct UK flights). Hepatitis A, Typhoid, and DTP can be given same-day for last-minute travellers. Plan 3–4 weeks ahead for Rabies if visiting Kruger.
May to September (dry winter season — best for safari as animals congregate around water sources). Cape Town and the Western Cape are best December to March (summer). October to May is the malaria risk season in the north-east.
Official recommendations from UK health authorities for travel to South Africa. Always consult a healthcare professional for advice tailored to your specific itinerary.
“A Yellow Fever vaccination certificate is required from travellers over 1 year of age arriving from countries with risk of Yellow Fever transmission.”
Accessed April 2026
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